Lionheart Health has announced a strategic partnership with Rejuvant, developer of patented Calcium alpha-ketoglutarate supplementation, as part of Lionheart's participation in the XPRIZE Healthspan Semi-Finals. The collaboration makes Rejuvant's CaAKG supplement a mandatory core component of both the Lionheart KLOTHO-UP™ Study and the broader Lionheart Klotho Wellness Program, which are central to Lionheart's XPRIZE Healthspan initiative. Lionheart Health was selected as one of 40 semi-finalists from more than 600 entries in spring 2025. The partnership represents a significant integration of clinically researched nutritional interventions with advanced healthspan technologies.
Rejuvant's CaAKG supplement has been associated with peer-reviewed research demonstrating improvements in biological age markers, providing a scientifically validated foundation for Lionheart's comprehensive approach. The Lionheart KLOTHO-UP™ Study integrates CaAKG supplementation within a multi-modal healthspan optimization framework designed to evaluate coordinated improvements across muscle, metabolic, immune, cardiovascular, and brain health domains. In addition to Rejuvant's supplement, all study participants receive SNiP Nutrition™ personalized supplements customized based on genetic and biomarker profiles, targeted Klotho-focused supplementation, and Lionheart Health's BodStim™ bioelectric exercise platform that delivers Klotho- and follistatin-elevating electrical muscle stimulation-enhanced exercise sessions.
This integrated approach reflects Lionheart's belief that meaningful healthspan extension requires both lifestyle optimization and advanced biological technologies working in concert. A spokesperson for Lionheart Health stated that Rejuvant's CaAKG platform represents one of the most rigorously studied nutritional interventions in the biological aging space and that by making it a mandatory core component, they are anchoring their program in validated metabolic biology while layering in advanced bioelectric, Klotho-focused, and personalized technologies. All enrollees undergo extensive testing and evaluation at baseline, 3 months, 6 months, and 12 months, including a 461-biomarker comprehensive blood panel, muscle health assessments, gut health and microbiome evaluation, blood sugar and metabolic regulation analysis, and brain health testing.
This longitudinal design enables objective tracking of functional healthspan changes over time rather than reliance on single-endpoint or short-duration outcomes. More information about the program can be found at https://lionheartlongevity.com/treatment/klotho-wellness-program/. A representative from Rejuvant expressed excitement about the partnership, noting that this collaboration allows CaAKG supplementation to be evaluated within one of the most comprehensive, biomarker-driven healthspan programs ever assembled. The partnership between these two companies represents a significant step forward in the scientific community's approach to healthspan extension, combining validated nutritional interventions with advanced technological platforms in a structured, measurable framework.
